Comparative Analysis of Techniques Oriented on the Recognition of Ligand Binding Area in Proteins - Identification of Ligand Binding Site and Protein-Protein Interaction Area - page 71

Fig. 4.10 Comparison of MCC and F-measure results for FMN-complexing proteins as reported
by ConSurf
complex form nor biological activity has been recognized as common for this group
of proteins (Table 4.2 ). Only the visual analysis of the 3-D structure presentation
suggest the well defined cavity in “easy” proteins.
The same must be concluded in respect to “hard” proteins. No criteria for this
group of proteins can be defined to characterize their specificity in respect to their
predictability (Table 4.3 ).
FMN binding site identification proved difficult for the following proteins shown
in Table 4.3 .
Top row (left to right): 2JHF, 1SBY, 3ABI (binding site easy to identify for most
programs)
Bottom row (left to right): 3P2O, 1EE9, 1 AD3 (binding site difficult to identify
for most programs)