Biology Reference
In-Depth Information
Fig. 4.2 Comparison of MCC and F-measure results for NAD + -complexing proteins as reported
by PocketFinder
High MCC values reported by Q-SiteFinder indicate accurate solutions, although
results were more varied than those obtained by CASTp. For several proteins MCC
values turned out negative, which suggests the majority of FN and FP (Fig. 4.3 ).
4.5.1.2
Knowledge-Based Tools
The validity of results derived by tracking evolutionary relationships falls in the
0.15-0.55 range, with only a single negative MCC result. Comparing MCC and
F-measure values indicates that both methods yield relatively similar results for a
broad range of proteins. We can conclude that the evolutionary approach is a useful
method for studying the properties of various proteins. On a more general level, it
seems that the generation of binding pockets in NAD + -complexing proteins is
significantly determined by evolutionary factors (Fig. 4.4 ).
Search WWH ::




Custom Search