Identi fication of Pockets on Protein Surface to Predict Protein–Ligand Binding Sites - Identification of Ligand Binding Site and Protein-Protein Interaction Area - page 34

Table 2.2 The success rates (%) of the top 3 predictions by metaPocket and 8 different methods on the 48 bound/unbound dataset, 210 bound dataset and 198
drug-target dataset

48 bound/unbound dataset 210 bound dataset 198 drug-target dataset

Method Top 1 Top 2 Top 3 Top 1 Top 2 Top 3 Top 1 Top 2 Top 3

MetaPocket 85/79 92/90 96/94 81 91 95 61 70 74

LIGSITE CS 81/ 71 90/ 79 92 / 85 70 81 88 48 57 61

PASS 58/58 79/65 83/77 51 71 79 35 50 56

Q-SiteFinder 75/52 83/60 90/75 72 85 90 40 54 62

SURFNET 42/42 56/58 60/62 42 53 57 24 30 34

GHECOM 67/67 81/77 83/81 63 73 79 39 51 56

ConCavity 75/ 73 81/ 81 83/83 73 81 84 47 53 56

Fpocket 65/56 79/77 81/85 61 73 81 31 48 57

POCASA 65/55 79/60 81/67 75 75 80 43 54 56