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very frequent mutations making its proteins unrecognizable for drugs applied in the
therapy so far. The monitoring of its mutations and consequent structural changes
with the procedures of new drug creation addressed against these modified proteins
of HIV virus may significantly speed up the therapeutic processes. The computer-
based tools presented in his topic when introduced to practical medicine will speed
up significantly the therapeutic processes making them individually addresses
against the “target” in the form as it appears in the patients body. Identification of
ligand binding sites in proteins as well as recognition of potential protein-protein
complexation area is the basis for individually designed therapy.
Acknowledgments This work was carried out in the context of the Virtual Laboratory for
e-Science project ( www.vl-e.nl ) supported by the BSIK grant of the Dutch Ministry of Education,
Culture and Science and ICT innovation program of the Ministry of Economic Affairs. Currently
this research is supported by the COMMIT project (WP8 and WP9). The authors are also grateful
to Piotr Nowakowski for his remarks.
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