In Silico Biology of Bone Regeneration Inside Calcium Phosphate Scaffolds - Tissue Engineering: Computer Modeling, Biofabrication and Cell Behavior - page 44

Ta b l e 1 Non-dimensionalized parameter values of the presented model (tildes are omitted for
simplicity)
Parameter Nominal value Source

MSCs

α m 1 Bailón-Plaza et al. [ 48 ]

A m 0 0.85 Bailón-Plaza et al. [ 48 ]

K m 0.1 Bailón-Plaza et al. [ 48 ]

a cm 5.98 measured

b cm 1.67 measured

c cm 3.33 measured

Y 11 10 Bailón-Plaza et al. [ 48 ]

H 11 14 Bailón-Plaza et al. [ 48 ]

F 11 8 Dvorak et al. [ 13 ]

F 12 1.5 Dvorak et al. [ 13 ]

d cm 1.5 estimated

Osteoblasts
A b 0 0.202 Bailón-Plaza et al. [ 48 ]

K b 0.1 Bailón-Plaza et al. [ 48 ]

α b 1 Bailón-Plaza et al. [ 48 ]

a cb 41.82 measured

b cb 5.06 measured

c cb 1.9 measured

d b 0.1 Bailón-Plaza et al. [ 48 ]

γ 7 measured

Collagen matrix

P bs 0.18 Yuan et al. [ 53 ]

κ b 1 Bailón-Plaza et al. [ 48 ]

Mineral matrix
δ

0.05 estimated

P bb 0.0398 Yuan et al. [ 53 ]

κ bb 1 Bailón-Plaza et al. [ 48 ]

m thres 0.85 estimated

scaling factor for the calcium concentration was assumed to be equal to the extra-
cellular calcium concentration ( Ca 0 =

1 mM). An overview of the model parameter
values and the initial variable values is given in Table 1 and Table 2 respectively.
The model parameters were non-dimensionalized as follows (the tildes represent
the non-dimensional parameters):