Uranium - Toxicology of Metals - page 879

of uranium, but the advantage is lost if treatment is
delayed 30 minutes. Compared with controls, 3,4,3-
LIHOPO reduced the uranium concentration to 23%
in kidney and 46% in bone versus respective values of
87% and 67% for sodium bicarbonate (Henge-Napoli
et al ., 1995). A 30-

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mol/kg dose of either of the two
LIHOPO decorporated 20% of injected uranyl nitrate
(Ramounet-Le Gall et al ., 2003). Studies have been con-
ducted to assess the usefulness of various multiden-
tate hydroxypyridine (HOPO), catecholamine (CAM),
and terphthalamide (TAM) ligands for uranium treat-
ment (Gordon et al ., 2003).
Phenyl acetate was reported to suppress the neo-
plastic transformation of immortalized human oste-
oblast cells to a tumorigenic phenotype by uranium
(Miller et al ., 2001). Because animal studies have not
identifi ed cancer as a health outcome after inhalation,
oral, or dermal exposure, the potential usefulness of
this agent for normal protective purposes is unclear.
A protein-monoclonal antibody combination was
found to increase the effectiveness of 2,9-dicarboxy-
1,10-phenanthroline (DCP) at chelating the uranyl ion,
while being selective for uranium over other metals.
Blake et al . (2004) took a murine protein and developed
three effi cient rat antibodies. After binding DCP to the
protein and allowing it to chelate uranyl ions from
solution, the complex was intraperitoneally injected
into rats. Subsequent injection of any of the antibod-
ies demonstrated a signifi cant affi nity, specifi city, and
high rate of complex formation for uranium ions com-
pared with other metals.

µ

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