Chemistry Reference
In-Depth Information
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Pershagen, 1985). By means of recent methods for iden-
tifi cation of genetic variation in populations, the role of
genetic polymorphisms is presently being examined in
relation to metal toxicology (Chapter 7). It is obvious that
such interactions occur frequently and can both increase
and decrease the toxicity of metals. For example, data
support the conclusion that the risk of chronic beryllium
disease developing is considerably increased among per-
sons belonging to a specifi c HLA group. Another exam-
ple is that selenium can decrease the toxicity of methylm-
ercury. Age seems to be an interaction factor of particular
importance. Several data indicate that the absorption of
both cadmium and lead is substantially higher in young
age groups than in other age groups. Children are more
susceptible to development of neurotoxic effect of lead
than adults (see Chapters 6, 7, and 31).
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