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TABLE 1
The LPO characteristics of the erythrocytes.
ShO mice
BE mice
Hemolysis, %
MDA, mmol/10
6
eryth.
Hemolysis, %
MDA, mmol/10
6
eryth.
before
incubation
after
incubation
before
incubation
after
incubation
before
incubation
after
incubation
before
incubation
after
incubation
11
22
3,1
3,9
11
17
4,1
5,5
12
18
3,7
4,7
17
16
4,5
9,1
12
12
3,5
3,5
18
17
4,5
4,4
10
23
3,5
3,9
12
17
3,7
2,9
10
16
3,7
3,7
19
28
5,5
3,8
Enhanced LPO rate against high liability of the membrane leads to further increas-
ing of the membrane À uidity, which testi¿ es failures in the system of LPO regulation
[6, 7].
Thus, phasic changes were found in the structural state of the BE mice erythrocyte
membranes. The phases of these changes correlate with the stages of the experimental
pathology development [8, 9] and with the phases of the forebrain membrane À uid-
ity alterations [1]. In addition, microviscosity of the erythrocyte, and synaptosomal
membranes are changing in opposite way for ShO mice. Consequently, structural state
of the erythrocyte membranes can be used as measure of the forebrain membrane
structural state.
5.4 CONCLUSION
We found phasic changes in the structural characteristics of the erythrocyte mem-
branes of mice involved in AD-like pathology. Those changes correlate with the stages
of “clinical” features and the phases of the forebrain membrane fluidity alterations.
Liability of the erythrocyte and synaptosomal membranes are changing in opposite
way for ShO mice. Thus, structural state of the erythrocyte membranes can be used
as measure of the forebrain membrane structural state. The obtained results testify
failures in the system of LPO regulation.
KEYWORDS
•
Alzheimer's disease
•
Lipid-protein interactions
•
Membrane fluidity
•
Membrane structure
•
Spin labeling
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