Chemistry Reference
In-Depth Information
21
A Study on Damage of
Chromosomes Activity
in Seedlings of
Crepis
Capillaris
Larissa I. Weisfeld and G. E. Zaikov
CONTENTS
21.1 Introduction ..................................................................................................... 261
21.2 Materials and Methodology............................................................................. 265
21.3 Discussion and Results .................................................................................... 266
21.4 Conclusion ....................................................................................................... 274
Keywords ................................................................................................................. 275
References ................................................................................................................ 275
21.1 INTRODUCTION
In this chapter, we attempt to consider mechanism of origin of rearrangement of chro-
mosome in the different phases of mitotic cycle. We are showing the appearance of
rearrangements of chromosome under the influence of antineoplastic medicament
phosphemid- di- (ethyleneimine)-pyrimidine-2-amino phosphoric acid, named muta-
gen. Seeds
Crepis capillaris
and fibroblasts of human and mouse were treating by this
mutagen. In seedlings on metaphase plates were analyzing rearrangements of chromo-
somes. The rearrangements were analyzed at different terms after appearance of seed-
lings named arisings. Also chromosomal rearrangements were examined at anaphases
and telophases of fibroblasts.
Scientists attracted attention to the chemical compounds that where cause heritable
changes. It remains unsolved mechanism of their effects on the chromosome. The ac-
tion of many compounds is similar with ionizing radiation, they are cause mutations of
genes, disruptions of cell division, and rearrangement of chromosomes.
The ethyleneimine and its derivatives
(DNA)
and proteins [1]. They induce mutations as it was shown in various model objects
(
Drosophila
, higher plants, fungi, bacteria, viruses, and others) and breakage of the
chromosome apparatus [2]. Chemical compounds that cause mutations and breakage
of chromosomes usually are called “chemical mutagens”.
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