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Melafen inÀ uences on both phases. The questions, what certain points of Ca
2+
-
transduction at rat thymocytes are involved to Melafen effects, do not closed. We may
conclude that P2X and P2Z Ca
2+
channel formed receptors are susceptible to Melafen
inÀ uence under a wide region of concentrations.
The additions of ATP to leucocytes suspension caused releasing of ɋɚ
2+
from intra-
cellular stores through activating of metabotropic P2Y purine receptors (at the medium
of measurement ɋɚ
2+
do not present). Thus, eliminated the possibility of introducing
to the cell interior the extra cellular Ca
2+
. We used the measurements medium without
the Ca
2+
ions. At this case the non-methabotrophic P2X and P2Z channel formers were
silent structure. And as itself will lead the P2Y methabotrophic receptor. What activate
the Ca
2+
ions releasing from intracellular Ca
2+
stores (endoplasmic reticulum). The
Melafen attendance shortens the time the phase lag up to cellular answer development.
The EAC cells behave analogously. Its go out to the stable behavior in the presence of
Melafen faster. Impact on Melafen to the channel former P2X the leucocytes receptors
are coming clear to up.
FIGURE 5
The influences of Melafen to the lag phase of cellular answers of leucocytes.
Kinetic curves of light scattering of the cell suspension under the wide concentrations region
of Melafen.
19.4 CONCLUSION
The Melafen actions to the three types of animal cells have the three global targets
P2Y, P2X, P2Z - purinoreceptors. Plant growth regulator has the negative actions to
the animal cells of different origin. And its actions were present under the low and
ultra low concentrations.
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