Biomedical Engineering Reference
In-Depth Information
Table 3.1
Biological activities reported for lasso peptides
Name
Producer
Class
a
Biological activities References
Lasso peptides
from actinobacteria
Siamycin
I/
MS-271/
NP-06
Streptomyces
sp.
I
Anti-HIV
Antibacterial
Inhibitor of myosin
light chain kinase
(Chokekijchai et al.
1995
;
Detlefsen et al.
1995
;
Tsunakawa et al.
1995
; Lin et al.
1996
;
Yano et al.
1996
)
Siamycin II
Streptomyces
sp.
I
Anti-HIV
Antibacterial
(Constantine et al.
1995
;
Tsunakawa et al.
1995
)
RP 71955/
Aborycin
Streptomyces sp.
I
Anti-HIV
Antibacterial
(Helynck et al.
1993
; Pot-
terat et al.
1994
)
Sviceucin/
SSV-2083
Streptomyces sviceus
I
Antibacterial
(Ducasse et al.
2012a
)
Anantin
Streptomyces
coerulescens
II
Atrial natriuretic
factor antagonist
(Weber et al.
1991
)
Propeptin
Microbispora
sp.
II
Prolyloligopeptidase
inhibitor
Weakly antibacterial
(Kimura et al.
1997a
)
Lariatin
Rhodococcus jostii
II
Antimycobacterial
(Iwatsuki et al.
2006
)
Sungsanpin
Streptomyces
sp.
II
Inhibitory activity
in a cell invasion
assay with a lung
cancer cell line
(Um et al.
2013
)
BI-32169
III
Glucagon receptor
antagonist
(Potterat et al.
2004
;
Knappe et al.
2010
)
Lasso peptides from proteobacteria
RES-701-1
RES-701-3
Streptomyces
sp.
II
Endothelin type
B receptor
antagonist
(Tanaka et al.
1994
;
Ogawa et al.
1995
)
Microcin J25
(MccJ25)
Escherichia coli
II
Antibacterial
RNA polymerase
inhibition
(Salomón and Farías
1992
; Bayro et al.
2003
; Rosengren et al.
2003
; Wilson et al.
2003
)
Capistruin
Burkholderia
thailandensis
II
Antibacterial
RNA polymerase
inhibition
(Knappe et al.
2008
;
Knappe et al.
2009
)
Astexin-1
Asticcacaulis
excentricus
II
Antibacterial
(Maksimov et al.
2012
)
a
The classification refers to the number of disulfide bridges that further stabilize the lasso struc-
ture and has been described in Chap. 2. Classes I, II and III are characterized by two, zero and one
disulfide bridge(s), respectively
ET
A
and ET
B
. The ET
A
and ET
B
receptors are G protein-coupled receptors (GPCRs)
with seven transmembrane domains. The ET
A
receptor binds ET-1 and ET-2 with
an affinity two orders of magnitude higher than that for ET-3 (
K
i
~ 0.01-0.1 and
1-3 nM, respectively), while the ET
B
receptor binds all three isoforms with similar
affinity (
K
i
~ 0.01-0.02 nM; Williams et al.
1991
; Schiffrin
2001
). In blood vessels,
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