Biology Reference
In-Depth Information
FIGURE 4.1
(A) NAD+ substrate of PARP1, illustrating the cleavage point and attachment points for the formation of linear or branched
polymer chains. (B) Cartoon of PARP1 binding to single strand break in DNA, leading to enzyme activation, cleavage of NAD+ with the
formation of negatively charged polymer and subsequent recruitment of other elements of single strand break repair.
Search WWH ::




Custom Search