Biology Reference
In-Depth Information
a challenge. Moreover, the question of whether aug-
menting DNA repair will negatively impact the anti-
cancer therapy remains to be determined. Given the
number of repair pathways, studies are warranted to
determine if pathways other than BER or NER would
be useful targets. Furthermore the role of mitochondria
and mitochondrial DNA repair deserves strong
consideration. Finally, the impact of the disease itself
on therapy-induced toxicity needs to be examined in
greater detail. Although we have come a long way in
identifying significant neurotoxicities induced by
cancer therapies, much clinical and basic work remains
to alleviate these debilitating consequences of cancer
treatment.
17. Tangpong J, Cole MP, Sultana R, et al. Adriamycin-induced, TNF-
alpha-mediated central nervous system toxicity. Neurobiol Dis
2006;
39.
18. Tsavaris N, Kosmas C, Vadiaka M, Kanelopoulos P,
Boulamatsis D. Immune changes in patients with advanced
breast cancer undergoing chemotherapy with taxanes. Br J Cancer
2002;
23
(1):127
e
7.
19. Jordan MA, Wilson L. Microtubules as a target for anticancer
drugs. Nat Rev Cancer 2004;
87
(1):21
e
4
65.
20. Keime-Guibert F, Napolitano M, Delattre JY. Neurological
complications of
(4):253
e
radiotherapy and chemotherapy.
J Neurol
708.
21. Seigers R, Fardell JE. Neurobiological basis of chemotherapy-
induced cognitive impairment: a review of rodent research.
Neurosci Biobehav Rev 2011;
1998;
245
(11):695
e
41.
22. Brooks PJ. DNA repair in neural cells: basic science and clinical
implications. Mutat Res 2002;
35
(3):729
e
108.
23. Kruman II , Schwartz EI. DNA damage response and neuro-
protection. Front Biosci 2008;
509
(1-2):93
e
13
15.
24. Kisby GE, Kabel H, Hugon J, Spencer P. Damage and repair of
nerve cell DNA in toxic stress. Drug Metab Rev 1999;
:2504
e
References
618.
25. Lu T, Pan Y, Kao SY, et al. Gene regulation and DNA damage in
the ageing human brain. Nature 2004;
31
(3):589
e
1. Ahles TA, Saykin AJ. Candidate mechanisms for chemotherapy-
induced cognitive changes. Nat Rev Cancer 2007;
201.
2. Dietrich J, Monje M, Wefel J, Meyers C. Clinical patterns and
biological correlates of cognitive dysfunction associated with
cancer therapy. Oncologist 2008;
7
(3):192
e
91.
26. Rao KS, Loeb LA. DNA damage and repair in brain: relationship
to aging. Mutat Res 1992;
429
(6994):883
e
29.
27. Bogdanov M, Brown RH, Matson W, et al. Increased oxidative
damage to DNA in ALS patients. Free Radic Biol Med
2000;
275
(3-6):317
e
95.
3. Weiss B. Chemobrain: a translational challenge for neuro-
toxicology. Neurotoxicology 2008;
13
(12):1285
e
8.
4. Windebank AJ, Grisold W. Chemotherapy-induced neuropathy. J
Periph Nerv Syst 2008;
29
(5):891
e
8.
28. Lyras L, Cairns NJ, Jenner A, Jenner P, Halliwell B. An assessment
of oxidative damage to proteins, lipids, and DNA in brain from
patients with Alzheimer's disease. J Neurochem 1997;
29
(7):652
e
46.
5. Park SB, Krishnan AV, Lin CS, Goldstein D, Friedlander M,
Kiernan MC. Mechanisms underlying chemotherapy-induced
neurotoxicity and the potential for neuroprotective strategies.
Curr Med Chem 2008;
13
(1):27
e
9.
29. Zhang J, Perry G, Smith MA, et al. Parkinson's disease is asso-
ciated with oxidative damage to cytoplasmic DNA and RNA in
substantia nigra neurons. Am J Pathol 1999;
68
(5):2061
e
94.
6. Wong CS, Van der Kogel AJ. Mechanisms of radiation injury to
the central nervous system: implications for neuroprotection. Mol
Interv 2004;
15
(29):3081
e
9.
30. Gabbita SP, Lovell MA, Markesbery WR. Increased nuclear DNA
oxidation in the brain in Alzheimer's disease.
154
(5):1423
e
J Neurochem
84.
7. Boulikas T, Vougiouka M. Cisplatin and platinum drugs at the
molecular level (Review). Oncol Rep 2003;
4
(5):273
e
40.
31. Wang J, Xiong S, Xie C, Markesbery WR, Lovell MA. Increased
oxidative damage in nuclear and mitochondrial DNA in
Alzheimer's disease. J Neurochem 2005;
1998;
71
(5):2034
e
82.
8. Cepeda V, Fuertes MA, Castilla J, Alonso C, Quevedo C,
Perez JM. Biochemical mechanisms of cisplatin cytotoxicity.
Anticancer Agents Med Chem 2007;
10
(6):1663
e
62.
32. Barzilai A, Biton S, Shiloh Y. The role of the DNA damage
response in neuronal development, organization and mainte-
nance. DNA Repair (Amst) 2008;
93
(4):953
e
18.
9. Feghali JG, Liu W, Van De Water TR. L-n-acetyl-cysteine protec-
tion against cisplatin-induced auditory neuronal and hair cell
toxicity. Laryngoscope 2001;
7
(1):3
e
27.
33. Fortini P, Dogliotti E. Mechanisms of dealing with DNA damage
in terminally differentiated cells. Mutat Res 2010;
7
(7):1010
e
111
55.
10. Jiang Y, Guo C, Vasko MR, Kelley MR. Implications of apurinic/
apyrimidinic endonuclease in reactive oxygen signaling response
after cisplatin treatment of dorsal root ganglion neurons. Cancer
Res 2008;
(7):1147
e
44.
34. Weissman L, Jo DG, Sorensen MM, et al. Defective DNA base
excision repair in brain from individuals with Alzheimer's
disease and amnestic mild cognitive impairment. Nucleic Acids
Res 2007;
685
(1-2):38
e
34.
11. Drablos F, Feyzi E, Aas PA, Vaagbo CB, Kavli B, Bratlie MS, et al.
Alkylation damage in DNA and RNA
68
(15):6425
e
(16). 5545-5.
35. Kisby GE, Milne J, Sweatt C. Evidence of reduced DNA repair in
amyotrophic
35
repair mechanisms and
medical significance. DNA Repair (Amst) 2004;
e
lateral
sclerosis
brain
tissue. Neuroreport
407.
12. Tewey KM, Rowe TC, Yang L, Halligan BD, Liu LF. Adriamycin-
induced DNA damage mediated by mammalian DNA top-
oisomerase II. Science 1984;
3
(11):1389
e
40.
36. Olkowski ZL. Mutant AP endonuclease in patients with amyo-
trophic lateral sclerosis. Neuroreport 1998;
1997;
8
(6):1337
e
42.
37. Lewen A, Sugawara T, Gasche Y, Fujimura M, Chan PH. Oxida-
tive cellular damage and the reduction of APE/Ref-1 expression
after
9
(2):239
e
8.
13. Fishel ML, Vasko MR, Kelley MR. DNA repair in neurons: so if
they don't divide what's
226
(4673):466
e
to repair? Mutat Res 2007;
614
experimental
traumatic brain injury. Neurobiol Dis
36.
14. Hetman M, Vashishta A, Rempala G. Neurotoxic mechanisms of
DNA damage: focus on transcriptional inhibition. J Neurochem
2010;
(1-2):24
e
90.
38. Morita-Fujimura Y, Fujimura M, Kawase M, Chan PH. Early
decrease in apurinic/apyrimidinic endonuclease is followed by
DNA fragmentation after cold injury-induced brain trauma in
mice. Neuroscience 1999;
2001;
8
(3):380
e
49.
15. McMurray CT. To die or not to die: DNA repair in neurons. Mutat
Res 2005;
114
(6):1537
e
73.
39. Kawase M, Fujimura M, Morita-Fujimura Y, Chan PH. Reduction
of apurinic/apyrimidinic endonuclease expression after transient
global cerebral ischemia in rats: implication of the failure of
93
(4):1465
74.
16. Pusztai L, Mendoza TR, Reuben JM, et al. Changes in plasma
levels of inflammatory cytokines in response to paclitaxel
chemotherapy. Cytokine 2004;
577
(1-2):260
e
e
25
(3):94
e
102.
