Biology Reference
In-Depth Information
285. Kaelin Jr WG. The concept of synthetic lethality in the context of
anticancer therapy.
Nat Rev Cancer
2005;
5
:689
e
98.
286. McCabe N, Turner NC, Lord CJ, et al. Deficiency in the repair of
DNA damage by homologous recombination and sensitivity to
poly(ADP-ribose) polymerase inhibition.
Cancer Res
2006;
66
:
8109
e
15.
287. Williamson CT, Muzik H, Turhan AG, et al. ATM deficiency
sensitizes mantle cell lymphoma cells to poly(ADP-ribose) poly-
merase-1 inhibitors.
Mol Cancer Ther
2010;
9
:347
e
57.
288. Weston VJ, Oldreive CE, Skowronska A, et al. The PARP inhibitor
olaparib induces significant killing of ATM-deficient lymphoid
tumor cells in vitro and in vivo.
Blood
2010;
116
:4578
e
87.
289. Chaudhry MA, Dedon PC, Wilson III DM, Demple B, Weinfeld M.
Removal by human apurinic/apyrimidinic endonuclease 1 (Ape 1)
and
Escherichia coli
exonuclease III of 3'-phosphoglycolates
from DNA treated with neocarzinostatin, calicheamicin, gamma-
radiation.
Biochem Pharmacol
1999;
57
:531
e
8.
290. Williamson LM, Williamson CT, Lees-Miller SP. DNA double
strand break repair: mechanisms and therapeutic potential. In:
Khanna KK, Shiloh Y, editors.
The DNA damage response: Impli-
cations on cancer formation and treatment
. Berlin: Springer Science
lymphoma in DNA-PKcs-deficient mice.
EMBO Rep
2004;
5
:
503
e
9.
304. Li XL, Shen SR, Wang S, Ouyang HH, Li GC. Restoration of Tcell-
specific V(D)J recombination in DNA-PKcs(-/-) mice by ionizing
radiation: the effects on survival, development, tumorigenesis.
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai)
2002;
34
:149
e
57.
305. Gao Y, Sun Y, Frank KM, et al. A critical role for DNA end-joining
proteins in both lymphogenesis and neurogenesis.
Cell
1998;
95
:
891
e
902.
306. Barnes DE, Stamp G, Rosewell I, Denzel A, Lindahl T. Targeted
disruption of the gene encoding DNA ligase IV leads to lethality
in embryonic mice.
Curr Biol
1998;
8
:1395
e
8.
307. Frank KM, Sekiguchi JM, Seidl KJ, et al. Late embryonic lethality
and impaired V(D)J recombination in mice lacking DNA ligase
IV.
Nature
1998;
396
:173
e
7.
308. Gao Y, Ferguson DO, Xie W, et al. Interplay of p53 and DNA-
repair protein XRCC4 in tumorigenesis, genomic stability and
development.
Nature
2000;
404
:897
e
900.
309. Frank KM, Sharpless NE, Gao Y, et al. DNA ligase IV deficiency
in mice leads to defective neurogenesis and embryonic lethality
via the p53 pathway.
Mol Cell
2000;
5
:993
e
1002.
310. Lee Y, McKinnon PJ. DNA ligase IV suppresses medulloblastoma
formation.
Cancer Res
2002;
62
:6395
e
9.
311. Frappart PO, Lee Y, Russell HR, et al. Recurrent genomic alter-
ations characterize medulloblastoma arising from DNA double-
strand break repair deficiency.
Proc Natl Acad Sci USA
2009;
106
:1880
e
5.
312. Rooney S, Sekiguchi J, Zhu C, et al. Leaky Scid phenotype asso-
ciated with defective V(D)J coding end processing in Artemis-
deficient mice.
Mol Cell
2002;
10
:1379
e
90.
313. Rooney S, Sekiguchi J, Whitlow S, et al. Artemis and p53 coop-
erate to suppress oncogenic N-myc amplification in progenitor B
cells.
Proc Natl Acad Sci USA
2004;
101
:2410
e
5.
314. Woo Y, Wright SM, Maas SA, et al. The nonhomologous end
joining factor Artemis suppresses multi-tissue tumor formation
and prevents loss of heterozygosity.
Oncogene
2007;
26
:6010
e
20.
315. Li G, Alt FW, Cheng HL, et al. Lymphocyte-specific compensa-
tion for XLF/cernunnos end-joining functions in V(D)J recombi-
nation.
Mol Cell
2008;
31
:631
e
40.
316. Xing J, Wu X, Vaporciyan AA, Spitz MR, Gu J. Prognostic
significance of ataxia-telangiectasia mutated, DNA-dependent
protein kinase catalytic subunit, Ku heterodimeric regulatory
complex 86-kD subunit expression in patients with nonsmall cell
lung cancer.
Cancer
2008;
112
:2756
e
64.
317. Korabiowska M, Quentin T, Schlott T, Bauer H. Kunze, E. Down-
regulation of Ku 70 and Ku 80 mRNA expression in transitional
cell carcinomas of
รพ
Business Media; 2009. p. 157
e
77.
291. Ouyang H, Nussenzweig A, Kurimasa A, et al. Ku70 is required
for DNA repair but not for T cell antigen receptor gene recom-
bination in vivo.
J Exp Med
1997;
186
:921
e
9.
292. Gu Y, Seidl KJ, Rathbun GA, et al. Growth retardation and leaky
SCID phenotype of Ku70-deficient mice.
Immunity
1997;
7
:653
e
65.
293. Li GC, Ouyang H, Li X, et al. Ku70: a candidate tumor suppressor
gene for murine T cell lymphoma.
Mol Cell
1998;
2
:1
e
8.
294. Teoh NC, Dan YY, Swisshelm K, et al. Defective DNA strand
break repair causes chromosomal instability and accelerates liver
carcinogenesis in mice.
Hepatology
2008;
47
:2078
e
88.
295. Gu Y, Sekiguchi J, Gao Y, et al. Defective embryonic neurogenesis
in Ku-deficient but not DNA-dependent protein kinase catalytic
subunit-deficient mice.
Proc Natl Acad Sci USA
2000;
97
:2668
e
73.
296. Zhu C, Bogue MA, Lim DS, Hasty P, Roth DB. Ku86-deficient
mice exhibit severe combined immunodeficiency and defective
processing of V(D)J recombination intermediates.
Cell
1996;
86
:
379
e
89.
297. Nussenzweig A, Sokol K, Burgman P, Li L, Li GC. Hypersensi-
tivity of Ku80-deficient cell lines and mice to DNA damage: the
effects of ionizing radiation on growth, survival, development.
Proc Natl Acad Sci USA
1997;
94
:13588
e
93.
298. Vogel H, Lim DS, Karsenty G, Finegold M, Hasty P. Deletion of
Ku86 causes early onset of senescence in mice.
Proc Natl Acad Sci
USA
1999;
96
:10770
e
5.
299. Lim DS, Vogel H, Willerford DM, Sands AT, Platt KA, Hasty P.
Analysis of ku80-mutant mice and cells with deficient levels of
p53.
Mol Cell Biol
2000;
20
:3772
e
80.
300. Holcomb VB, Vogel H, Marple T, Kornegay RW, Hasty P. Ku80
and p53 suppress medulloblastoma that arise independent of
Rag-1-induced DSBs.
Oncogene
2006;
25
:7159
e
65.
301. Taccioli GE, Amatucci AG, Beamish HJ, et al. Targeted disruption
of the catalytic subunit of the DNA-PK gene in mice confers
severe
the urinary bladder
related to tumor
progression.
World J Urol
2004;
22
:431
e
40.
318. Ye C, Cai Q, Dai Q, et al. Expression patterns of the ATM gene in
mammary tissues and their associations with breast cancer
survival.
Cancer
2007;
109
:1729
e
35.
319. Shi JY, Ren ZH, Jiao B, et al. Genetic variations of DNA repair
genes and their prognostic significance in patients with acute
myeloid leukemia.
Int J Cancer
2011;
128
:233
e
8.
320. Jiang Z, Hu J, Li X, Jiang Y, Zhou W, Lu D. Expression analyses of
27 DNA repair genes in astrocytoma by TaqMan low-density
array.
Neurosci Lett
2006;
409
:112
e
7.
321. Kang B, Guo RF, Tan XH, Zhao M, Tang ZB, Lu YY. Expression
status of ataxia-telangiectasia-mutated gene correlated with
prognosis in advanced gastric cancer.
Mutat Res
2008;
638
:17
e
25.
combined immunodeficiency
and radiosensitivity.
Immunity
1998;
9
:355
e
66.
302. Gao Y, Chaudhuri J, Zhu C, Davidson L, Weaver DT, Alt FW. A
targeted DNA-PKcs-null mutation reveals DNA-PK-independent
functions for KU in V(D)J recombination.
Immunity
1998;
9
:
367
e
76.
303. Espejel S, Martin M, Klatt P, Martin-Caballero J, Flores JM,
Blasco MA. Shorter telomeres, accelerated ageing and increased
