Biology Reference
In-Depth Information
129. Pawelczak KS, Bennett SM, Turchi JJ. Coordination of DNA-PK
activation and nuclease processing of DNA termini in NHEJ.
Antioxid Redox Signal ; 2010. December 2 [Epub ahead of print].
130. Zhang Z, Hu W, Cano L, Lee TD, Chen DJ, Chen Y. Solution
structure of the C-terminal domain of Ku80 suggests important
sites for protein-protein interactions. Structure (Camb) 2004; 12 :
495 e 502.
131. Harris R, Esposito D, Sankar A, et al. The 3D solution structure of
the C-terminal region of Ku86 (Ku86CTR). J Mol Biol 2004; 335 :
573 e 82.
132. Falck J, Coates J, Jackson SP. Conserved modes of recruitment of
ATM, ATR and DNA-PKcs to sites of DNA damage. Nature
2005; 434 :605 e 11.
133. Gell D, Jackson SP. Mapping of protein-protein interactions
within the DNA-dependent protein kinase complex. Nucleic Acids
Res 1999; 27 :3494 e 502.
134. Hammel M, Yu Y, Mahaney BL, et al. Ku and DNA-dependent
protein kinase dynamic conformations and assembly regulate
DNA binding and the initial non-homologous end joining
complex. J Biol Chem 2010; 285 :1414 e 23.
135. Weterings E, Verkaik NS, Keijzers G, et al. The Ku80 carboxy
terminus stimulates joining and artemis-mediated processing of
DNA ends. Mol Cell Biol 2009; 29 :1134 e 42.
136. Roberts SA, Strande N, Burkhalter MD, et al. Ku is a 5'-dRP/AP
lyase that excises nucleotide damage near broken ends. Nature
2010; 464 :1214 e 7.
137. Sibanda BL, Chirgadze DY, Blundell TL. Crystal structure of
DNA-PKcs reveals a large open-ring cradle comprised of HEAT
repeats. Nature 2010; 463 :118 e 21.
138. Boskovic J, Rivera-Calzada A, Maman JD, et al. Visualization of
DNA-induced conformational changes in the DNA repair kinase
DNA-PKcs. EMBO J 2003; 22 :5875 e 82.
139. Williams DR, Lee KJ, Shi J, Chen DJ, Stewart PL. Cryo-EM
structure of the DNA-dependent protein kinase catalytic subunit
at subnanometer resolution reveals alpha helices and insight into
DNA binding. Structure 2008; 16 :468 e 77.
140. Kienker LJ, Shin EK, Meek K. Both V(D)J recombination and
radioresistance require DNA-PK kinase activity, though minimal
levels
148. Yu Y, Mahaney BL, Yano K, et al. DNA-PK and ATM phos-
phorylation sites in XLF/Cernunnos are not required for repair of
DNA double strand breaks. DNA Repair (Amst) 2008; 7 :1680 e 92.
149. Wang YG, Nnakwe C, Lane WS, Modesti M, Frank KM. Phos-
phorylation and regulation of DNA ligase IV stability by DNA-
dependent protein kinase. J Biol Chem 2004; 279 :37282 e 90.
150. Goodarzi AA, Yu Y, Riballo E, et al. DNA-PK autophosphor-
ylation facilitates Artemis endonuclease activity. EMBO J
2006; 25 :3880 e 9.
151. Meek K, Dang V, Lees-Miller SP. DNA-PK: the means to justify
the ends? Adv Immunol 2008; 99 :33 e 58.
152. Chan DW, Lees-Miller SP. The DNA-dependent protein kinase is
inactivated by autophosphorylation of the catalytic subunit. J Biol
Chem 1996; 271 :8936 e 41.
153. Merkle D, Douglas P, Moorhead GB, et al. The DNA-dependent
protein kinase interacts with DNA to form a protein-DNA
complex that is disrupted by phosphorylation. Biochemistry
2002; 41 :12706 e 14.
154. Douglas P, Cui X, Block WD, et al. The DNA-dependent protein
kinase catalytic subunit is phosphorylated in vivo on threonine
3950, a highly conserved amino acid in the protein kinase
domain. Mol Cell Biol 2007; 27 :1581 e 91.
155. Block WD, Yu Y, Merkle D, et al. Autophosphorylation-
dependent remodeling of the DNA-dependent protein kinase
catalytic subunit regulates ligation of DNA ends. Nucleic Acids
Res 2004; 32 :4351 e 7.
156. Chen BP, Chan DW, Kobayashi J, et al. Cell cycle dependence of
DNA-PK phosphorylation in response to DNA double strand
breaks. J Biol Chem 2005; 280 :14709 e 15.
157. Chan DW, Chen BP, Prithivirajsingh S, et al. Autophosphor-
ylation of the DNA-dependent protein kinase catalytic subunit is
required for rejoining of DNA double-strand breaks. Genes Dev
2002; 16 :2333 e 8.
158. Ma Y, Pannicke U, Lu H, Niewolik D, Schwarz K, Lieber MR. The
DNA-dependent protein kinase catalytic subunit phosphoryla-
tion sites in human Artemis. J Biol Chem 2005; 280 :33839 e 46.
159. Douglas P, Sapkota GP, Morrice N, et al. Identification of in vitro
and in vivo phosphorylation sites in the catalytic subunit of the
DNA-dependent protein kinase. Biochem J 2002; 368 :243 e 51.
160. Neal JA, Dang V, Douglas P, Wold MS, Lees-Miller SP, Meek K.
Inhibition of HR by DNA-PK requires kinase activity, is titratable,
is modulated by autophosphorylation. Mol Cell Biol 2011; 31 (8):
1719 e 33.
161. Meek K, Douglas P, Cui X, Ding Q, Lees-Miller SP. trans Auto-
phosphorylation at DNA-dependent protein kinase's two major
autophosphorylation site clusters facilitates end processing but
not end joining. Mol Cell Biol 2007; 27 :3881 e 90.
162. Dobbs TA, Tainer JA, Lees-Miller SP. A structural model for
regulation of NHEJ by DNA-PKcs autophosphorylation. DNA
Repair (Amst) 2010; 9 :1307 e 14.
163. Meek K, Gupta S, Ramsden DA, Lees-Miller SP. The DNA-
dependent protein kinase: the director at the end. Immunol Rev
2004; 200 :132 e 41.
164. Ding Q, Reddy YV, Wang W, et al. Autophosphorylation of the
catalytic subunit of the DNA-dependent protein kinase is
required for efficient end processing during DNA double-strand
break repair. Mol Cell Biol 2003; 23 :5836 e 48.
165. Uematsu N, Weterings E, Yano K, et al. Autophosphorylation of
DNA-PKCS regulates its dynamics at DNA double-strand breaks.
J Cell Biol 2007; 177 :219 e 29.
166. Junop MS, Modesti M, Guarne A, Ghirlando R, Gellert M,
Yang W. Crystal structure of the Xrcc4 DNA repair protein and
implications for end joining. EMBO J 2000; 19 :5962 e 70.
suffice for V(D)J
recombination. Nucleic Acids Res
2000; 28 :2752 e 61.
141. Kurimasa A, Kumano S, Boubnov NV, et al. Requirement for the
kinase activity of human DNA-dependent protein kinase cata-
lytic subunit in DNA strand break rejoining. Mol Cell Biol
1999; 19 :3877 e 84.
142. Zhao Y, Thomas HD, Batey MA, et al. Preclinical evaluation of
a potent novel DNA-dependent protein kinase inhibitor NU7441.
Cancer Res 2006; 66 :5354 e 62.
143. O'Connor MJ, Martin NM, Smith GC. Targeted cancer therapies
based on the inhibition of DNA strand break repair. Oncogene
2007; 26 :7816 e 24.
144. Yu Y, Wang W, Ding Q, et al. DNA-PK phosphorylation sites in
XRCC4 are not required for survival after radiation or for V(D)J
recombination. DNA Repair (Amst) 2003; 2 :1239 e 52.
145. Douglas P, Gupta S, Morrice N, Meek K, Lees-Miller SP. DNA-
PK-dependent phosphorylation of Ku70/80 is not required for
non-homologous end joining. DNA Repair (Amst) 2005; 4 :1006 e 18.
146. Berglund FM, Clarke PR. hnRNP-U is a specific DNA-dependent
protein kinase substrate phosphorylated in response to DNA
double-strand breaks. Biochem Biophys Res Commun 2009; 381 :
59 e 64.
147. Britton S, Froment C, Frit P, Monsarrat B, Salles B, Calsou P. Cell
nonhomologous end joining capacity controls SAF-A phosphor-
ylation by DNA-PK in response to DNA double-strand breaks
inducers. Cell Cycle 2009; 8 :3717 e 22.
Search WWH ::




Custom Search