Biology Reference
In-Depth Information
TABLE 8.1 Phenotypes of Mouse Strains Carrying Knockout Mutations of NHEJ Genes
Genotype
Tumors
Other observations
References
Ku70
/
T cell lymphoma
Accelerated liver carcinogenesis in diethylnitrosamine
treated mice
Retarded growth
Arrested B cell development
Impaired V(D)J recombination
Elevated radiosensitivity
Defective embryonic neurogenesis
291-295
Ku80
/
Early onset of lymphoma
Retarded growth
Premature aging
Arrested B and T cell development
Impaired V(D)J recombination
Defective embryonic neurogenesis
Elevated radiosensitivity
105, 295-298
Ku80
/
p53
þ
/
Earlier onset of various cancers than
p53
þ
/
mice
Shorter lifespan than
Ku80
/
mice
299
Ku80
/
p53
/
Pro-B-cell lymphoma
(medulloblastoma in
Ku80
Very short lifespan
MEFs are radiosensitive
299, 300
/
p53
/
rag1
/
triple
mutants)
DNA-PKcs
/
T cell lymphoma
Normal growth
Compromised B and T cell development
Impaired V(D)J recombination
Normal embryonic neurogenesis
Elevated radiosensitivity
295, 301-304
XRCC4
/
Embryonic lethal due to a
p53
-dependent
response to DNA damage
Severe defective embryonic neurogenesis
MEFs are radiosensitive
295, 305-307
XRCC4
/
p53
þ
/
Retarded growth
Short lifespan (nutritional problems)
Compromised B and T cell development
308
XRCC4
/
p53
/
Pro-B-cell lymphoma
Retarded growth
Short lifespan (lymphoma)
Compromised B and T cell development
308
Lig4
/
Embryonic lethal due to a
p53
-dependent
response to DNA damage
Severe defective embryonic neurogenesis
295, 307
Lig4
/
p53
þ
/
Retarded growth
Short lifespan
Compromised B and T cell development
309
Lig4
/
p53
/
Pro-B-cell lymphoma
medulloblastoma
Retarded growth
Short lifespan
Compromised B and T cell development
Normal embryonic neurogenesis
Radiosensitive
309-311
Artemis
/
Normal size
Compromised B and T cell development
Impaired V(D)J recombination
MEFs are radiosensitive
312
Artemis
/
p53
/
Pro-B-cell lymphoma
Short lifespan
313
Artemis
/
p53
þ
/
Pro-B-cell lymphoma. Differentiated and anaplastic sarcoma
Shorter lifespan than
p53
þ
/
mice
314
