Targeting Homologous Recombination Repair in Cancer - DNA Repair in Cancer Therapy - page 147

Acknowledgments
The authors wish to thank Natalie Ferraiolo and Liliana Gheorghiu
for critical reading of the manuscript. HW would like to thank Dr
Simon N. Powell for his inspiring teachings.

22. Zhang F, Ma J, Wu J, et al. PALB2 links BRCA1 and BRCA2 in the
DNA-damage response. Curr Biol 2009;19(6):524 e 9.
23. Wesoly J, Agarwal S, Sigurdsson S, et al. Differential contribu-
tions of mammalian Rad54 paralogs to recombination, DNA
damage repair, and meiosis. Mol Cell Biol 2006;26(3):976 e 89.
24. Heyer WD, Li X, Rolfsmeier M, Zhang XP. Rad54: the Swiss
Army knife of homologous recombination? Nucleic Acids Res
2006;34(15):4115 e 25.
25. Lin Z, Kong H, Nei M, Ma H. Origins and evolution of the recA/
RAD51 gene family: evidence for ancient gene duplication and
endosymbiotic gene transfer. Proc Natl Acad Sci USA 2006;103(27):
10328 e 33.
26. Liu Y, Tarsounas M, O'Regan P, West SC. Role of RAD51C and
XRCC3 in genetic recombination and DNA repair. J Biol Chem
2007;282(3):1973 e 9.
27. Gari K, Decaillet C, Stasiak AZ, Stasiak A, Constantinou A. The
Fanconi anemia protein FANCM can promote branch migration
of Holliday junctions and replication forks. Mol Cell 2008;29(1):
141 e 8.
28. Bugreev DV, Mazina OM, Mazin AV. Rad54 protein promotes
branch migration of Holliday junctions. Nature 2006;442(7102):
590 e 3.
29. Bugreev DV, Brosh Jr RM, Mazin AV. RECQ1 possesses DNA
branch migration activity. J Biol Chem 2008;283(29):20231 e 42.
30. Raynard S, Zhao W, Bussen W, et al. Functional role of BLAP75 in
BLM-topoisomerase III alpha-dependent holliday junction pro-
cessing. J Biol Chem 2008;283(23):15701 e 8.
31. Munoz IM, Hain K, Declais AC, et al. Coordination of structure-
specific nucleases by human SLX4/BTBD12 is required for DNA
repair. Mol Cell 2009;35(1):116 e 27.
32. Fekairi S, Scaglione S, Chahwan C, et al. Human SLX4 is a Hol-
liday junction resolvase subunit that binds multiple DNA repair/
recombination endonucleases. Cell 2009;138(1):78 e 89.
33. Svendsen JM, Smogorzewska A, Sowa ME, et al. Mammalian
BTBD12/SLX4 assembles a Holliday junction resolvase and is
required for DNA repair. Cell 2009;138(1):63 e 77.
34. Andersen SL, Bergstralh DT, Kohl KP, LaRocque JR, Moore CB,
Sekelsky J. Drosophila MUS312 and the vertebrate ortholog
BTBD12 interact with DNA structure-specific endonucleases in
DNA repair and recombination. Mol Cell 2009;35(1):128 e 35.
35. Ip SC, Rass U, Blanco MG, Flynn HR, Skehel JM, West SC.
Identification of Holliday junction resolvases from humans and
yeast. Nature 2008;456(7220):357 e 61.
36. Svendsen JM, Harper JW. GEN1/Yen1 and the SLX4 complex:
Solutions to the problem of Holliday junction resolution. Genes
Dev 2010;24(6):521 e 36.
37. Lee JH, Paull TT. ATM activation by DNA double-strand breaks
through the Mre11-Rad50-Nbs1 complex. Science 2005;308(5721):
551 e 4.
38. Bakkenist CJ, Kastan MB. DNA damage activates ATM through
intermolecular autophosphorylation and dimer dissociation.
Nature 2003;421(6922):499 e 506.
39. Kozlov SV, Graham ME, Jakob B, et al. Autophosphorylation and
ATM activation: Additional sites add to the complexity. J Biol
Chem 2011;286:9107 e 19.
40. Kozlov SV, Graham ME, Peng C, Chen P, Robinson PJ, Lavin MF.
Involvement of novel autophosphorylation sites in ATM activa-
tion. EMBO J 2006;25(15):3504 e 14.
41. Shiotani B, Zou L. Single-stranded DNA orchestrates an ATM-
to-ATR switch at DNA breaks. Mol Cell 2009;33(5):547 e 58.
42. Zou L, Elledge SJ. Sensing DNA damage through ATRIP recog-
nition of RPA-ssDNA complexes. Science 2003;300(5625):1542 e 8.
43. Zhao S, Weng YC, Yuan SS, et al. Functional link between ataxia-
telangiectasia and Nijmegen breakage syndrome gene products.
Nature 2000;405(6785):473 e 7.

References

1. Ciccia A, Elledge SJ. The DNA damage response: making it safe
to play with knives. Mol Cell 2010;40(2):179 e 204.
2. San Filippo J, Sung P, Klein H. Mechanism of eukaryotic
homologous recombination. Annu Rev Biochem 2008;77:229 e 57.
3. West SC. Molecular views of recombination proteins and their
control. Nat Rev Mol Cell Biol 2003;4(6):435 e 45.
4. Hartlerode AJ, Scully R. Mechanisms of double-strand break
repair in somatic mammalian cells. Biochem J 2009;423(2):157 e 68.
5. Mimitou EP, Symington LS. DNA end resection e unraveling the
tail. DNA Repair (Amst) ; 2011 (in press).
6. You Z, Bailis JM. DNA damage and decisions: CtIP coordinates
DNA repair and cell cycle checkpoints. Trends Cell Biol 2010;20(7):
402 e 9.
7. Cejka P, Cannavo E, Polaczek P, et al. DNA end resection by
Dna2-Sgs1-RPA and its stimulation by Top3-Rmi1 and Mre11-
Rad50-Xrs2. Nature 2010;467(7311):112 e 6.
8. Niu H, Chung WH, Zhu Z, et al. Mechanism of the ATP-
dependent DNA end-resection machinery from Saccharomyces
cerevisiae. Nature 2010;467(7311):108 e 11.
9. Nicolette ML, Lee K, Guo Z, et al. Mre11-Rad50-Xrs2 and Sae2
promote 5' strand resection of DNA double-strand breaks.
Nat Struct Mol Biol 2010;17(12):1478 e 85.
10. Shim EY, Chung WH, Nicolette ML, et al. Saccharomyces cer-
evisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association
of Exo1 and Dna2 with DNA breaks. EMBO J 2010;29(19):
3370 e 80.
11. Myers JS, Cortez D. Rapid activation of ATR by ionizing radiation
requires ATM and Mre11. J Biol Chem 2006;281(14):9346 e 50.
12. Jazayeri A, Falck J, Lukas C, et al. ATM- and cell cycle-dependent
regulation of ATR in response to DNA double-strand breaks.
Nat Cell Biol 2006;8(1):37 e 45.
13. Sartori AA, Lukas C, Coates J, et al. Human CtIP promotes DNA
end resection. Nature 2007;450(7169):509 e 14.
14. Eid W, Steger M, El-Shemerly M, et al. DNA end resection by
CtIP and exonuclease 1 prevents genomic instability. EMBO Rep
2010;11(12):962 e 8.
15. Gravel S, Chapman JR, Magill C, Jackson SP. DNA helicases Sgs1
and BLM promote DNA double-strand break resection. Genes Dev
2008;22(20):2767 e 72.
16. Zou L. DNA repair: A protein giant in its entirety. Nature 2010;
467(7316):667 e 8.
17. Thorslund T, McIlwraith MJ, Compton SA, et al. The breast
cancer tumor suppressor BRCA2 promotes the specific targeting
of RAD51 to single-stranded DNA. Nat Struct Mol Biol 2010;
17(10):1263 e 5.
18. Jensen RB, Carreira A, Kowalczykowski SC. Purified human
BRCA2 stimulates RAD51-mediated recombination. Nature 2010;
467(7316):678 e 83.
19. Liu J, Doty T, Gibson B, Heyer WD. Human BRCA2 protein
promotes RAD51 filament formation on RPA-covered single-
stranded DNA. Nat Struct Mol Biol 2010;17(10):1260 e 2.
20. Zhang F, Fan Q, Ren K, Andreassen PR. PALB2 functionally
connects the breast cancer susceptibility proteins BRCA1 and
BRCA2. Mol Cancer Res 2009;7(7):1110 e 8.
21. Sy SM, Huen MS, Chen J. PALB2 is an integral component of the
BRCA complex required for homologous recombination repair.
Proc Natl Acad Sci USA 2009;106(17):7155 e 60.