Biomedical Engineering Reference
In-Depth Information
has recently been expanded to include these capabilities [
259
]. Further enhance-
ments can include the incorporation of growth and remodeling, diffusive processes,
and even interaction with the microvasculature.
In the future, multiscale models of ligaments and tendons offer many possible
applications. Perhaps the most immediate need, as detailed in this chapter, is the
investigation of structure and function across physical scales as it related to mechan-
ics. Additional lines of inquiry related to structure-function relationships include
the role of different noncollagenous constituents such as elastin [
168
] and the small
leucine-rich PGs [
102
,
106
,
107
,
176
,
177
]. Once multiscale models with the major
structural features and components have been constructed and validated, they offer
the opportunity to provide substantial insight into the mechanical and biological
processes associated with injury, healing, immobilization, optimization of treatment
regimens, and the engineering of replacement tissues.
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