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US, so there will soon be many more mutants available. Deafness is one of
the most heterogeneous diseases known in humans, and study of the many
deaf mouse mutants will help unravel the molecular basis of the pathology,
an essential first step towards a rational approach to treatment.
Acknowledgments.
This work was supported by the UK Medical Research
Council, the European Commission, and Defeating Deafness. We thank the
people who have kindly allowed us to include their data prior to publica-
tion, including Drs. Ken Johnson, Yin Zheng, Verity Letts, Wayne Frankel,
Jo Cable, Rachel Hardisty, Matthew Kelley, Douglas Forrest and David
Beier, and Donna Fekete for kind permission to reprint Figure 8.1.
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