Biology Reference
In-Depth Information
semicircular canal. These defects can affect the determination of cell fate
in the neuroepithelium, the differentiation of cell types, the sculpting of the
tissues as they develop, or the function of the various cell types, including
hair cells. Table 8.3 lists the mouse mutants with this type of abnormality.
TABLE 8.3. Mouse mutants with neuroepithelial defects
Key
Mutant name
Symbol
Gene
Chromosome
Inheritance
Origin
references
Integrin a8 KO
Itga8
Itga8
2
R
T
1
Activating
Atf 2
,
Atf 2
2
R
T
2
transcription factor
Creb2
2 KO
Modifier of tubby
Moth1
NK
2 (69)
R
S
3
hearing 1
Tailchaser
Tlc
NK
2 (77)
SD
C
4
Varitint-waddler
Va
NK
3 (74.8)
SD
S
5-7
Maloney sarcoma
Mos
Mos
4 (0)
SD
T
8, 9
oncogene KO
Whirler
wi
NK
4 (31.4)
R
S
10
Jerker
je
NK
4 (80.1)
R
S
11-13
Fibroblast growth
Fgfr3
Fgfr3
5 (20)
R
T
14
factor receptor
3 KO
Pirouette
pi
NK
5 (40)
R
S
15, 16
Nicotinic acetyl
Acra9
Acra9
5 (41)
R
T
17
choline receptor
a9 KO
Bronx waltzer
bv
NK
5 (63)
R
S
18-29
Atonal homolog 1
Atoh1
,
Atoh1
6 (30)
R
T
30
KO
Math1
Deafwaddler, Wriggle
dfw
,
wri
,
Atp2b2
6 (49.5)
R, SD
S
31-33
mouse Sagami,
Pmca2
,
Pmca2
KO
Atp2b2
Cyclin dependent
Cdkn1b
Cdkn1b
6 (62)
R
T
34, 35
kinase inhibitor
p27
Kip1
1B KO
Cartilage matrix
cmd
,
Agc
7 (39)
R
36, 37
deficiency
Agc
Shaker1
Myo7a
,
Myo7a
7 (48.1)
R
S, C
38-47
sh1
Tubby
tub
,
tub
7 (51.45)
R
S
48-51
CBT9
Snell's waltzer
sv
,
Myo6
Myo6
9 (44)
R
S, R
52-54
Spinner
sr
NK
9 (64)
R
S
55
Waltzer, Bustling
v
,
bus
NK
10 (30.3)
R
S, C
56-61
Modifier of
mdfw
NK
10 (30.3)
R, E
S
62
deafwaddler
Age-related hearing
Ahl
NK
10 (33)
R
S
63-66
Loss
Ames waltzer
av
NK
10 (40.2)
R
S
67, 68
Mocha
mh
,
Ap3d
Ap3d
10 (43)
R, M
S
69-71
Shaker2
sh2
,
Myo15
Myo15
11 (33.9)
R
R, S
72-74
Jackson shaker
js
NK
11 (77)
R
S
75-78
