Biology Reference
In-Depth Information
TABLE 8.1. Mouse mutants with middle ear or pinna defects
Key
Mutant name
Symbol
Gene
Chromosome
Inheritance
Origin
references
Otocephaly
oto
NK
1
R,E
R
1,2
Eyes absent 1
Eya1
Eya1
1 (10.4)
SD
T
3, 4
homologue KO
Gli2
KO
Gli2
Gli2
1 (63)
R
T
5
Prx2
KO
Prx2, S8
Prx2
2 (19)
R, E
T
6
First arch
far
NK
2 (40)
SD
S
7, 8
malformation
Distal-less
Dlx1
Dlx1
2 (44)
R, E
T
9
homeobox 1 KO
Distal-less
Dlx2
Dlx2
2 (44)
R, E
T
9
homeobox 2 KO
Flaky tail
ft
NK
3 (41.4)
R
S
12
Droopy ear
de
NK
3 (48.8)
R
S
13
Dominant reduced
Dre
NK
4
SD
R
12
ear
Perlecan KO
Hspg2
,
Plc
Hspg2
4 (71.4)
R
T
14
Homeobox, msh-
Msx1, Hox7
Msx1
5 (21)
R
T
15
like KO
Dlx5
KO
Dlx5
Dlx5
6 (2)
R
T
16, 17
Homeobox A1 KO
Hoxa1
Hoxa1
6 (26.3)
R, E
T
18-22
Homeobox A2 KO
Hoxa2
Hoxa2
6 (26.3)
R
T
23-26
Head bobber
hb
NK
7 (65)
R
I
27
Short ear
se
,
Bmp5
Bmp5
9 (42)
R
S, R
28, 29
Apoptotic protease
Apaf1
Apaf1
10
R
T
30
activating factor
1 KO
Hemifacial
Hfm
NK
10
SD
I
31
microsomia-
associated
locus
Homeobox B1 KO
Hoxb1
Hoxb1
11 (56)
R, E
T
32-35
Homeobox B2 KO
Hoxb2
Hoxb2
11 (56)
R
T
36
Collagen type 1
a1
Cola1
Cola1
11 (56)
D
T, I
37-39
KO, Mov-13
Mov-13
Retinoic acid
Rara
Rara
11 (57.8)
R, E
T
40-42
receptor a KO
Pax9
KO
Pax9
Pax9
12 (26)
R
T
43
Goosecoid KO
gsc
gsc
12 (52)
R
T
44-46
Endothelin 1
Edn1
,
Et1
Edn1
13 (26)
R
T
47
Homeobox,
Msx2
,
Hox8
Msx2
13 (32)
D
T
48
msh-like 2 KO
Cartilage link
Crtl1
Crtl1
13 (44)
R
T
49
protein 1 KO
Retinoic acid
Rarb
Rarb
14
R, E
T
40-42
receptor b KO
Orthodenticle
Otx2
Otx2
14 (19)
SD, E
T
50-52
homologue-2 KO
Hairy ears
Eh
NK
15
SD
R
12
