As-Produced Intrinsic Physico-Chemical Properties and Appropriate Characterization Tools - Safety of Nanomaterials along Their Lifecycle - page 12

× 10 6 × 10 6

File: Q135001.dat SIO 2 FITC 25 nm core File: Q135502.dat SIO 2 FITC 25 nm core

1.2

Si

0.8 1.0

0.8

0.6
0.4
0.2

0.6

SiOH 0.4

Si

0.2

20 30 40 50 60 10 15 20 25 30 35 40

Mass/u Mass/u

× 10 5

× 10 4

SiO 2

1.4
1.2
1.0
0.8
0.6
0.4
0.2

5.0

4.0
3.0
1.0

2.0

50 60 70 80 90 100 110 120

70 80 90 100 110 120 130 140 150

Mass/u Mass/u

× 10 3 × 10 3

FITC FITC-specifc

5.0

0.8
0.4
0.2

4.0
3.0
2.0
1.0

0.6

Au

180 200 220 240 260 280 140 160 180 200 220 240

Mass/u Mass/u

× 10 1

× 10 2

3.0
2.5
2.0
1.5

6.0

5.0
4.0
3.0
2.0
1.0

1.0
0.5

300 320 340 360 380 400 420 440 460 260 280 300 320 340 360 380 400

Mass/u

Mass/u

× 10 1 × 10 1

3.0

2.5
2.0
1.5
1.0
0.5

1.5
1.0

0.5

500 550 600 650 420 440 460 480 500 520 540 560 580

Mass/u

Mass/u

Mass/u

FIGURE 1.8 Secondary ion mass spectrometry (SIMS) analysis of silica nanoparticles (NanoGEM.SiO 2 .FITC); positive (left) and negative (right)
pola r it y.