Case Study Paints and Lacquers with Silica Nanoparticles - Safety of Nanomaterials along Their Lifecycle - page 391

TABLE 17.2
Examples of Toxicity of Silica Manufactured Nanomaterials in Experimental Animals

Surface
Modiication

Silica Type Size Dose Test System Main Effect Reference

Silica nanoparticles 50 nm

50 nm
200 nm
200 nm

-
NH 2
-
NH 2

30 µg/animal Intratracheal instillation

of particles in different
dispersion media; male
Sprague Dawley rats

50 nm particles resulted in
increased neutrophil inlux when
particles were dispersed in BSA
and saline. >200 nm particles
gave no response

Brown et al.
(2014)

Colloidal silica
Bindzil ® CC30 (Akzo
Nobel Chemicals)

a 7 nm; 6.5 nm
diluted 1:9 in
Nanopure water

Organo-modiied 54 µg/mouse

(2.8 mg/kg)

Intratracheal
instillation; female
C57BL/6

No inlammation and DNA
damage 24 h after instillation

Saber et al.
(2012a)

Axilat Ultraine
LS5000
(Hexion Specialty
Chemicals B.V.)

a <50 nm; 5.6 nm
diluted 1:9 in
Nanopure water

Acrylate
(1,6-hexanediol
diacrylate)

54 µg/mouse
(2.8 mg/kg)

Intratracheal
instillation; female
C57BL/6

Increased pulmonary inlux of
neutrophils and inlammation but
no DNA damage 24 h after
instillation

(Saber et al.
2012a)

Pure HiSilTM T700
nanosilica (SiNP)
(Degussa GmbH)
and Cd-coated SiNP
(SiNP-Cd)

Original SiNPs:
20 nm pore size

32.5 wt% Cd SiNPs:

(600 µg/rat)

Intratracheal
instillation; male
Sprague-Dawley rats

Oxidative lung tissue injury and
inlammatory effects at 30 days
post- exposure as observed from
F2-IsoPs SOD1, iNOS, COX-2,
granuloma, and stromal
ibrogenic reaction

Coccin et al.
(2012)

Cd-treated
SiNPs: 20-80
nm primary
particle size
(200 m 2 /g)

SiNPs-Cd:
(1 mg/rat,
corresponding to
about 250 µg
Cd/rat)

Pure silica SiNPs did not inluence
any of the evaluated end points

a Data according to the supplier.