Concern-Driven Safety Assessment of Nanomaterials - Safety of Nanomaterials along Their Lifecycle - page 372

the AOP for different NMs is essential both for the elaboration of suitable in vitro
methods as well as to promote the grouping of NMs. The same holds for in vitro and
in silico tools that assess the changes in physicochemical characteristics and bio-
kinetic profile. Suitable individual concepts for grouping should be integrated into
comprehensive decision-tree guidance for grouping of NMs, including parameters
for efficient acquisition of data supporting the grouping of NMs. Whereas such sci-
entifically sound grouping criteria will undoubtedly form the “heart” of grouping
and IATA, their definition will take time to develop and criteria will only evolve
while applied. Guidance should be developed on what information is sufficient for a
risk assessment of a group of NMs. Finally, grouping requires a set of information
of at least one material, which serves as a reference for the whole group of NMs.
ACKNOWLEDGMENTS
This topic chapter is based on the work performed at the EU projects NanoSafety
Vision and MARINA. The work of the project members is greatly appreciated. The
NanoSafety Vision report has been published (Oomen et al. 2013); Dr. Ursula Sauer
has helped to assemble and edit the manuscript.
REFERENCES
Ankley GT, Bennett RS, Erickson RJ, Hoff DJ, Hornung MW, Johnson RD, Mount DR,
Nichols JW, Russom CL, Schmieder PK, Serrrano JA, Tietge JE, Villeneuve DL. (2010).
Adverse outcome pathways: A conceptual framework to support ecotoxicology research
and risk assessment. Env Toxicol Chem 29:730-741.
Anon. (2006). Regulation (EC) No 1907/2006 of the European Parliament and of the
Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation
and Restriction of Chemicals (REACH), establishing a European Chemicals Agency,
amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93
and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC
and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC. O.J.
L 396/1, 30 December 2006.
Anon. (2010). Directive 2010/63/EU of the European Parliament and of the Council of 22
September 2010 on the protection of animals used for scientific purposes. O.J. L 276/33,
20 October 2010.
Anon. (2011). Commission recommendation on the definition of nanomaterial. OJ L 275/38,
18 October 2011.
Card JW, Magnuson BA. (2010). A method to assess the quality of studies that examine the
toxicity of engineered nanomaterials. Int J Toxicol 29:402-410.
Castranova V, Schulte PA, Zumwalde RD. (2012). Occupational Nanosafety Considerations
for Carbon Nanotubes and Carbon Nanofibers. AccChem Res 5 December 2012, epub
ahead of print.
Combes, R, Balls M. (2005). Intelligent testing strategies for chemicals testing-a case of more
haste, less speed? ATLA 33:289-297.
Combes R, Barratt M, Balls M. (2003). An overall strategy for the testing of chemicals for
human hazard and risk assessment under the EU REACH system. ATLA 31:7-19.
CTTAEA, NRC. (2007). Committee on Toxicity Testing and Assessment of Environmental
Agents, US National Research Council. Toxicity Testing in the 21st Century: A
Vision and a Strategy. National Academics Press, 216 pp. http://www.nap.edu/catalog.
php?record_id=11970#toc.