Concern-Driven Safety Assessment of Nanomaterials - Safety of Nanomaterials along Their Lifecycle - page 355

16 Concern-Driven

Safety Assessment
of Nanomaterials
An Integrated Approach
Using Material Properties,
Hazard, Biokinetic,
and Exposure Data and
Considerations on Grouping
and Read-Across

Agnes Oomen, Peter Bos, and Robert Landsiedel

CONTENTS
16.1 Introduction .................................................................................................. 358
16.2 Nanomaterial Toxicity Pathways and Adverse Outcome Pathways ............. 361
16.3 Grouping of NM ........................................................................................... 364
16.3.1 Concept of Grouping ........................................................................ 364
16.3.2 Grouping of NM: Ongoing Developments ....................................... 365
16.4 Integrated Approaches for Nanomaterial Safety Testing and Assessment ... 367
16.4.1 Identification of “NM of Concern” ................................................... 367
16.4.2 Assessment of NM Human Health Hazards ..................................... 371
16.4.3 Assessment of NM Biokinetics......................................................... 371
16.4.4 Specific Testing Based upon the Outcome of Tiers 1 and 2 ............. 372
16.5 Outlook ......................................................................................................... 373
Acknowledgments .................................................................................................. 374
References .............................................................................................................. 374

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