Toxicological Effects of Metal Nanomaterials - Safety of Nanomaterials along Their Lifecycle - page 205

2013a; Alkilany et al. 2009). The coating chemicals may act as toxic agents them-
selves, diminish the release of ions, or alter the adsorption of biomolecules such as
proteins or lipids, which then could influence the particle-cell interaction.
Taken together, the picture emanating from the findings described earlier is
that the toxicity of metal nanoparticles is driven by physicochemical properties of
nanoparticles. Thus, size, solubility, and surface coating may act in concert on bio-
distribution and secondary biological responses, which share many components with
metal ion toxicity.
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