Toxicological Effects of Metal Oxide Nanomaterials - Safety of Nanomaterials along Their Lifecycle - page 162

TABLE 8.2
Summary of Effects of Metal Oxide Nanoparticles on Cultured or Primary
Cells

Property
Involved Nanoparticle Effect Cell Lines Tested Reference

TiO 2 , Fe 2 O 3 ,
CO 3 O 4 , Mn 3 O 4

Oxidative stress A549 Chemical

composition

Limbach et al.
2007

TiO 2 -ZrO 2 Oxidative stress See Table 8.1, CaCO 2 ,

CaLu3, MDCK II

Chemical
composition

Kroll et al. 2011

ZnO, SiO 2 Oxidative stress Primary mouse

fibroblasts

Chemical
composition

Yang et al. 2009

ZnO Oxidative stress BEAS-2B, RAW

264.7

Solubility Xia et al. 2008

ZnO Oxidative stress BEAS-2B Huang et al. 2010

Rutile TiO 2 ,
anatase TiO 2

Oxidative stress A549, human dermal

fibroblasts (HDF)

Crystalline
structure

Sayes et al. 2006

Anatase TiO 2 Oxidative stress See Table 8.1, CaCO 2 ,

CaLu3, MDCK II

Surface
modification

Kroll et al. 2011

TiO 2 Oxidative stress Primary dermal

fibroblasts

Surface
modification

Pan et al. 2009

CeO 2 Oxidative stress See Table 8.1, CaCO 2 ,

CaLu3, MDCK II

Surface
chemistry

Kroll et al. 2011

SiO 2 .naked Induction of protein

carbonyls

NRK-52E Surface

modification

nanoGEM, final
report

ZnO, TiO 2 Induction of protein

carbonyls

NRK-52E nanoGEM, final

report

TiO 2 , Al 2 O 3 Cell viability/

metabolic activity

A549 Chemical

composition

Simon-Deckers
et al. 2008

SiO 2 Cell viability/

metabolic activity

EAHY926, HUVEC,
human blood cells

Jaganathan and
Godin 2012

SiO 2 Cell viability/

metabolic activity

A549, EAHY926,
J774

Size/surface area Lin et al. 2006

ZnO, CuO,
Cu 2 O, Zn 2 TiO 4

Cell viability/
metabolic activity

A549, THP-1 Solubility Lanone et al.

2009

ZnO Cell viability/

metabolic activity

L2 lung epithelial
cells

Solubility Sayes, Reed, and

Warheit 2007

ZnO Cell viability/

metabolic activity

Neuro-2A Solubility Jeng and Swanson

2006

ZnO Cell viability/

metabolic activity

HK-2 human renal
cells

Solubility Kermanizadeh

et al. 2013

Rutile TiO 2 ,
anatase TiO 2

Cell viability/
metabolic activity

A549 Crystalline

structure

Simon-Deckers
et al. 2008

ZnO Cell viability/

metabolic activity

See Table 8.1 nanoGEM, final

report

SiO 2 .naked Cell viability/

metabolic activity

RAW 264.7 Surface

modification

nanoGEM, final
report

( Continued )