Chemistry Reference
In-Depth Information
5 mol% Cu(OAc)
2
5 g SiO
2
10 min, 800 min
-1
R
1
N
R
1
R
2
+
N
3
N
N
1 mmol
R
2
1.1 mmol
84-91%
17 examples
Scheme 1.26 Copper-catalyzed 1,3-dipolar cycloaddition of alkynes and azides
forming 1,4-substituted-1H-1,2,3-triazoles.
R
5 mol% Cu(OAc)
2
5 mol% Na-ascorbate
5 g SiO
2
20 min, 800 min
-1
N
N
N
N
N
N
3
N
3
12
N
R
+
12
n
1 mmol
1 mmol
Scheme 1.27 Polymerization of 1,12-diazidododecane and bis-ethynyl compounds
in ball mill.
R
1
Cu/Al
2
O
3
(10 mol%
)
N
N
N
R
1
+
R
2
H
X
NaN
3
600 rpm, 1h
R
2
70-96%
16 examples
R
1
= alkyl
R
2
= alkyl, aryl
Cu/Al
2
O
3
K
2
CO
3
, NaN
3
600 rpm, 1h
R
3
N
N
600 rpm, 1 h
R
3
-N
3
R
3
-B(OH)
2
+
R
2
N
H
R
2
R
3
= aryl, alkenyl, heteroaryl
83-91%
7 examples
Some representative examples:
N
N
N
N
N
N
N
N
N
S
S
N
N
N
83%
78%
87%
Scheme 1.28 Cu/Al
2
O
3
catalyzed one-pot synthesis of 1,2,3-triazoles.
Ar
2
O
Ar
3
NaHSO
4
.H
2
O
High speed ball milling
(HSBM)
NH
2
Ar
1
Ar
1
Ar
2
+
N
H
N
N
Ar
3
82-93%
13 examples
Scheme 1.29 Mechanochemical synthesis of 1,3,5-triaryl-2-pyrazolines catalyzed by
NaHSO
4
H
2
O.
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