Chemistry Reference
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R
2
R
2
O
O
EDC·HCl (1.0 equiv), DMAP (2.0 equiv)
NaCl (20 equiv), MeNO
2
(0.25
μ
L/mL)
BocHN
OBn
BocHN
OBn
OH
Ts ·
H
2
N
H
p
Ball-mill, 3 h, 30Hz
R
1
R
1
O
O
O
O
O
BocHN
BocHN
BocHN
OBn
OBn
OBn
N
H
N
H
N
H
O
O
O
Boc-
L
-Ala-Gly-OBn
78%
Boc-
D
-Ala-Gly-OBn
79%
Boc-Gly-Gly-OBn
70%
O
O
BocHN
BocHN
OBn
OBn
N
H
N
H
O
O
Boc-
L
-Ala-
L
-Ala-OBn
80%
Boc-
D
-Ala-
L
-Ala-OBn
81%
Scheme 6.21 Mechanosynthesis of dipeptides from non-preactivated a-amino acids.
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