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O
O
BocN
BocHN
OMe
O
N
H
NaHCO
3
(1.5 equiv)
OMe
+
CO
2
+
NaCl
HCl·
H
2
N
O
Vibrating ball-mill, 30 Hz, 1 h
O
O
Boc-Phe-NCA
HCl·H-Ala-OMe
Boc-Phe-Ala-OMe
99% conversion
79% yield
Scheme 6.13 Mechanosynthesis of Boc-Phe-Ala-OMe.
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