Chemistry Reference
In-Depth Information
1) CDI (1.0 equiv)
O
O
2) R
2
R
3
NH
.
HCl (0.9 equiv)
R
2
+
2
HN
N
+
HCl
R
1
R
1
OH
N
3) H
2
O
4) Filtration
R
3
CO
2
O
N
N
N
N
HN
N
CDI
CO
2
Ph
O
O
O
N
R
1
= Boc-Phe-OH
HCl
.
H
2
N-Phe-O
t
Bu
CO
2
t
Bu
Boc
H
H
R
1
N
N
R
1
=
Ph
Ph
41
49%,
de>
95%
39
40
78%,
ee
98%
H
2
N
Scheme 6.11 CDI-mediated mechanosynthesis of amides.
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