Chemistry Reference
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Pd(OAc)
2
5 mol%
OMe
OMe
R
1
H
O
M
2
CO
3
(2 equiv, M = K, Cs)
PM100, 550 rpm, 7 h
5 steel balls, 7 mm O
NaHCO
3
/ HCO
2
Na
P
O
n-
BuN
4
Cl / NaCl
OMe
OMe
OMe
+
R
1
-I
+
BocHN
BocHN
BocHN
800 rpm, 1 h, 8 steel balls
R
1
H
O
O
R
1
= Aryl
O
22
R
1
= Alkyl, Aryl
10 examples
61-95%
23
24
15 examples
61-88%
N(Me)
2
(Me)
2
N
OMe
R
2
R
2
I
2
(1.1 equiv)
mortar grinding
6-60 min
OMe
H
H
O
O
25
9 examples
33-99%
26
Scheme 6.7
Solvent-free synthesis of unsaturated amino esters and 2-carboxy-substituted indoles.
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