Environmental Engineering Reference
In-Depth Information
Fig. 3.8 Assignment of reads to the NCBI taxonomy. (Reproduced from http://ab.inf.uni-tuebingen.de/software/
megan5/ )
References
of microorganisms. It provides pathway-related
information in various simpler forms; it also pro-
vides a graphical view of the output, which can
be grasped easily. For studies related to metage-
nomics, we discussed the MEGAN tool which
simplifies huge datasets into simple short ones
by using shotgun techniques. MEGAN provides
a simple solution to the complex problem of
metagenomic study. Due to these fast and reli-
able computational tools, various advancements
are taking place in the field of Pathways Analy-
sis and Metagenomics, making them the central
paradigm of biological research.
Handelsman J (2004) Metagenomics: application of
genomics to uncultured microorganisms. Microbiol
Mol Biol Rev 68(4):669-685
Huson Author: DH, Auch AF, Ji Qi, Schuster SC (2007)
MEGAN analysis of metagenomic data. Genome Res
17(3):377-386
Karp PD, Paley S, Romero P (2002) The pathway tool
software. Bioinformatics 18(Suppl 1):225-232
Papin AJ, Price DN, Palsson ￘B (2002) Extreme pathway
lengths and reaction participation in genome-scale
metabolic networks. Genome Res 12(12):1889-1900
Pfeiffer T, Sanchez-Valdenebro I, Nuno JC et al (1999)
METATOOL: for studying metabolic networks. Bio-
informatics 15:251-257
 
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