Modeling Biochemical Pathways - Mathematical Approaches to Polymer Sequence Analysis and Related Problems - page 125

to both the number of parameters included in the model and model sensitivity to
parameters value variations. Among the parameter estimation techniques, the evo-
lutionary computations proved to be a good solution to handle this task. As the
number of parameters increases, it is crucial to use high performance computing or
high throughput computing to find candidate solutions to this problem.

Acknowledgements The authors are supported by the NET2DRUG, MIUR-FIRB LITBIO

(RBLA0332RH), ITALBIONET (RBPR05ZK2Z), BIOPOPGEN (RBIN064YAT) and CNR-

BIOINFORMATICS initiatives.

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