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In Depth Tutorials and Information
(a) 4(R)-Hyp
OH
N
N
C
C
O
O
Fe
2+
O
O
HO
HO
OH
OH
O
O
O
2
CO
2
(b) 3(S)-Hyp
(c) 5-Hydroxylysine
NH
2
OH
H
2
C
OH
CH
CH
2
N
H
2
C
C
CH
O
H
C
O
(d) galactosylhydroxylysine
(e) glucosylgalactosylhydroxylysine
NH
2
OH
OH
NH
2
O
H
CH
2
OH
O
OH
O
H
CH
2
HC
O
H
HO
H
OH
HC
H
CH
2
H
O
H
OH
H
H
CH
2
CH
2
H
HO
N
CH
2
HO
CH C
H
N
H
CH C
H
O
H
O
O
H
OH
OH
FIGURE 6.2
Post-translational modifications occurring in the collagen triple helix. The prolyl 4-hydroxylation reaction is shown in (a). The
structures of 3-hydroxyproline (b), hydroxylysine (c), galactosyl-hydroxylysine (d), and glucosylgalactosyl-hydroxylysine (e) are shown.
