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(A)
(B)
(C)
(D)
(E)
(F)
FIGURE 44.17 Nineteen-year-old male with type IV OI who presented with low back pain. He ambulated from age 2 to 5, then stopped,
and began ambulating again at age 16. Treated with multiple doses of Aredia. (A, B) Noted to have spondylolisthesis of lower lumbar vertebra
at multiple levels with a markedly abnormal flexed posture on AP and lateral spine X-rays at age 19. (C) Sitting lateral at age 9 showing ver-
tebral changes and elongated pedicles but no listhesis. (D) Sitting lateral at age 19 with severe pedicle elongation and multiple
level
listhesis.
(E) Severely elongated pedicles and listhesis on CT with auto fusion of posterior elements. (F) CT showing chronic spondylolysis at level above
the rigid auto fusion.
imperfecta: clinical and histomorphometric outcome. J Bone
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[6] Aström E, Jorulf H, Söderhäll S. Intravenous pamidronate treat-
ment of infants with severe osteogenesis imperfecta. Arch Dis
Child 2007;92(4):332-8.
[7] Plotkin H. Syndromes with congenital brittle bones. BMC
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[8] Rauch F, Plotkin H, Zeitlin L, Glorieux F. Bone mass, size, and
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fecta: effects of intravenous pamidronate therapy. J Bone Min
Res 2003;4:610-4.
[9] Glorieux FH. Osteogenesis imperfecta. Best Pract Res Clin
Rheumatol 2008;22:85-100.
References
[1] Yong-Hing K, MacEwen GD. Scoliosis associated with osteo-
genesis imperfecta: results of treatment. J Bone Joint Surg Br
1982;64B:36-43.
[2] Benson D, Donaldson DH, Millar EA. The spine in osteogenesis
imperfecta. J Bone Joint Surg 1978;60A(7):925-9.
[3] Benson D, Newman DC. The spine and surgical treatment in
osteogenesis imperfecta. Clin Orthop Rela Res 1981;159:147-53.
[4] Renshaw TS, Cook RS, Albright JA. Scoliosis in osteogenesis
imperfecta. Clini Orthop Rela Res 1979;145:163-7.
[5] Munns CF, Rauch F, Travers R, Glorieux FH. Effects of intra-
venous pamidronate treatment in infants with osteogenesis
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