what-when-how
In Depth Tutorials and Information
was 4 weeks. The analgesic effect of iloprost and tra-
madol was similar. BME regression on MR images was
more pronounced under iloprost treatment. On MR
images, 3 months after initiating treatment, complete
BME regression in at least one bone was observed in nine
patients (52.9%) in group 1, as opposed to three patients
(18.7%) in group 2.
Meiser treated individuals with edema of the femur
head with a series of five iloprost infusions, 20 to 50 μg
iloprost over 6 hours on 5 consecutive days each.
33
At
clinical follow-up 4 months after therapy, the pain level
at rest had diminished by a mean of 58.3%. Pain under
stress decreased by a mean of 41.9% (
P
<0.0001). On
MRI, 20 patients had a significant reduction of BME size
or complete normalization and four showed no change.
Worsening of the MRI pattern was found in three
patients.
[10]
[11]
[12]
[13]
[14]
[15]
[16]
CONCLUSION
[17]
TMO affects both females and males, the former usu-
ally in the context of pregnancy and the latter in middle
age. The disorder is self-limiting and reversible, but has
a potentially significant impact on patients with OI by
virtue of increasing disability. The real incidence in the
OI population is unknown. This disorder should be
considered in OI patients who experience rapid onset of
hip pain or pain in other joints. Prompt diagnosis and
treatment may lessen the pain, improve function and
promote resolution of bone edema seen on MRI.
[18]
[19]
[20]
[21]
References
[22]
[23]
[24]
[25]
[26]
[27]
[28]
[29]
