what-when-how
In Depth Tutorials and Information
O
THER JOINT INVOLVEMEN
T
There have been few case reports of other forms of
arthritis in patients with OI. Three patients with OI tarda
were reported to have hyperuricemia and gout.
27
There
has been one case report of a relapsing inflammatory
monoarthritis in a knee of a 47-year-old man with OI.
28
There was also a case reported of a 14-year-old girl who
developed severe osteoporosis and destructive general-
ized arthritis, initially concerning for juvenile rheuma-
toid arthritis, but later thought to be a variant of OI with
chronic arthropathy.
29
There has also been a case reported
of a 51-year-old woman with knee pain and stiffness and
hand deformities suggestive of rheumatoid arthritis but
without any hand pain or morning stiffness.
30
Beighton and colleagues reported a study of 153 sub-
jects with OI from 84 families in South Africa in order to
document the skeletal complications.
31
Seventy-nine of
153 patients had mild type I OI. They are described to
have mild orthopedic complications and relatively nor-
mal stature with fewer fractures and deformities. Twenty-
one patients with type III OI had multiple fractures, trunk
shortening and severe kyphoscoliosis. Seventeen patients
had type IV OI and were handicapped secondary to bone
fragility and long bone bowing.
One hundred women with OI with a total of 213
pregnancies between 1957 and 1998 were interviewed
by phone to assess musculoskeletal problems that they
may have encountered during the pregnancy. This
study showed that the majority of the pregnancies were
in women with type I OI and the most common symp-
tom recorded was back pain. There was no relationship
between the severity of the pain and the Sillence type
of OI. Height loss, disc prolapse and fractures were also
reported and one woman developed recurrent ankle
sprains thought to be secondary to ligamentous laxity.
32
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References
[22]
[23]
[24]
[25]
[26]
[27]
