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recurrent uterine rupture in pregnancy. Am J Obstet Gynecol
2003;189:594-600.
[3] Krishnamoorthy U, Vausse S, Donnai P. Management of preg-
nancy complicated by maternal osteogenesis imperfecta: report
of a case with uterine rupture. J Obstet Gynecol 2002;22:316-22.
[4] Sharma A, George L, Erskin K. Osteogenesis imperfecta in preg-
nancy: two case reports and review of literature. Obstet Gynecol
Surv 2001;56:563-6.
[5] Soma K, Abe H, Takeda N, et  al. Myocardial involvement in
patients with osteogenesis imperfecta. Int Heart J 2012;53:75-7.
[6] Nicholls AC, Osse G, Schloon HG, et al. The clinical features of
homozygous alpha 2(I) collagen deicient osteogenesis imper-
fecta. J Med Genet 1984;21:257-62.
[7] Chipman SD, Sweet HO, McBride Jr DJ, et  al. Defective pro
alpha 2(I) collagen synthesis in a recessive mutation in mice: a
model of human osteogenesis imperfecta. Proc Natl Acad Sci
USA 1993;90:1701-5.
[8] Gentry BA, Ferreira JA, McCambridge AJ, Brown M, Phillips
CL. Skeletal muscle weakness in osteogenesis imperfecta mice.
Matrix Biol 2010;29:638-44.
[9] Engelbert RH, van der Graaf Y, van Empelen R, Beemer FA,
Helders PJ. Osteogenesis imperfecta in childhood: impairment
and disability. Pediatrics 1997;99:E3.
[10]
Engelbert RH, Beemer FA, van der Graaf Y, Helders PJ.
Osteogenesis imperfecta in childhood: impairment and
disability - a follow-up study. Arch Phys Med Rehabil
1999;80:896-903.
FIGURE 37.1 T2-weighted MRI of the knee of a 24-year-old
patient with type I OI with a torn ACL. Although the torn ACL is
not visible, a peripheral meniscus tear and degeneration with bone
edema are observed.
[11]
Engelbert RH, Gulmans VA, Uiterwaal CS, Helders PJ.
Osteogenesis imperfecta in childhood: perceived competence in
relation to impairment and disability. Arch Phys Med Rehabil
2001;82:943-8.
[12]
Takken T, Terlingen HC, Helders PJ, Pruijs H, Van der Ent CK,
Engelbert RH. Cardiopulmonary itness and muscle strength
in patients with osteogenesis imperfecta type I. J Pediatr
2004;145:813-8.
the latter of which is detectable via X-ray diffraction. 30
Differences in tendon biomechanical strength became
apparent at high levels of strain. 29
Ligament injuries are even less frequently reported
than tendon injuries, perhaps due to decreased injury
severity. However, medial collateral ligament 22 and
anterior cruciate ligament (ACL) tears ( Figure 37.1 )
have been reported. 31
[13]
Engelbert RH, Pruijs HE, Beemer FA, Helders PJ. Osteogenesis
imperfecta in childhood: treatment strategies. Arch Phys Med
Rehabil 1998;79:1590-4.
[14]
Montpetit K, Plotkin H, Rauch F, et  al. Rapid increase in
grip force after start of pamidronate therapy in children and
adolescents with severe osteogenesis imperfecta. Pediatrics
2003;111:e601-3.
[15]
Glorieux FH, Bishop NJ, Plotkin H, Chabot G, Lanoue G,
Travers R. Cyclic administration of pamidronate in chil-
dren with severe osteogenesis imperfecta. N Engl J Med
1998;339:947-52.
CONCLUSION
[16]
Dupuy C, Lauwers-Cances V, Abellan Van Kan G, et al. Dietary
vitamin D intake and muscle mass in older women. Results
from a cross-sectional analysis of the EPIDOS study. J Nutr
Health Aging 2013;17(2):119-24.
Muscle, tendon and ligament pathologies affecting
both the lower and upper extremities are seen in OI
patients. Ruptured Achilles tendons, anterior cruciate
ligament tears and shoulder injuries due to constant
wheelchair use are not uncommon in the OI population.
Within this patient population, allograft-assisted surgi-
cal repair of similar injuries has been successful.
[17]
McKiernan FE. Musculoskeletal manifestations of mild
osteogenesis imperfecta in the adult. Osteoporos Int
2005;16:1698-702.
[18]
Cabral WA, Makareeva E, Letocha AD, et  al. Y-position cyste-
ine substitution in type I collagen (alpha1(I) R888C/p.R1066C)
is associated with osteogenesis imperfecta/Ehlers-Danlos syn-
drome phenotype. Hum Mutat 2007;28:396-405.
[19]
Kothari P, Mohan N, Hunter JB, Kerslake R. Case report.
Bilateral simultaneous patellar tendon ruptures associated with
osteogenesis imperfecta. Ann R Coll Surg Engl 1998;80:416-8.
References
[1] Boot AM, de Coo RF, Pals G, de Muinck Keizer-Schrama SM.
Muscle weakness as presenting symptom of osteogenesis imper-
fecta. Eur J Pediatr 2006;165:392-4.
[2] Di Lieto A, Pollio F, De Falco M, et  al. Collagen content
and growth factor immunoexpression in uterine lower seg-
ment of type IA osteogenesis imperfecta: relationship with
[20]
ElGuindy A, Lustig S, Servien E, et al. Treatment of chronic dis-
ruption of the patellar tendon in Osteogenesis Imperfecta with
allograft reconstruction. Knee 2011;18:121-4.
[21]
Nigrisoli M, Valdiserri L. Bilateral laceration of patellar ten-
don in a case of osteogenesis imperfecta. Chir Organi Mov
1988;73:259-63.
 
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