SERPINF1 as a Cause of Osteogenesis I mperfecta Type V I - Osteogenesis Imperfecta - page 156

[39] Gattu AK, Birkenfeld AL, Jornayvaz F, et al. Insulin resistance

is associated with elevated serum pigment epithelium-derived
factor (PEDF) levels in morbidly obese patients. Acta Diabetol
2012;49(Suppl. 1):S161-9.

[50] Bernard A, Gao-Li J, Franco CA, Bouceba T, Huet A, Li Z. Laminin

receptor involvement in the anti-angiogenic activity of pigment
epithelium-derived factor. J Biol Chem 2009;284(16):10480-90.

[51] Anguissola S, McCormack WJ, Morrin MA, Higgins WJ, Fox DM,

Worrall DM. Pigment epithelium-derived factor (PEDF) interacts
with transportin SR2, and active nuclear import is facilitated by a
novel nuclear localization motif. PloS One 2011;6(10):e26234.

[40] Tombran-Tink J, Pawar H, Swaroop A, Rodriguez I, Chader GJ.

Localization of the gene for pigment epithelium-derived fac-
tor (PEDF) to chromosome 17p13.1 and expression in cultured
human retinoblastoma cells. Genomics 1994;19(2):266-72. [52] Yabe T, Wilson D, Schwartz JP. NFkappaB activation is required

for the neuroprotective effects of pigment epithelium-derived
factor (PEDF) on cerebellar granule neurons. J Biol Chem
2001;276(46):43313-9.

[41] Tombran-Tink J, Mazuruk K, Rodriguez IR, et al. Organization,

evolutionary conservation, expression and unusual Alu den-
sity of the human gene for pigment epithelium-derived factor, a
unique neurotrophic serpin. Mol Vis 1996;2:11. [53] Volpert OV, Zaichuk T, Zhou W, et al. Inducer-stimulated Fas

targets activated endothelium for destruction by anti-angiogenic
thrombospondin-1 and pigment epithelium-derived factor. Nat
Med 2002;8(4):349-57.

[42] Petersen SV, Valnickova Z, Enghild JJ. Pigment-epithelium-

derived factor (PEDF) occurs at a physiologically relevant con-
centration in human blood: puriication and characterization.
Biochem J 2003;374(Pt 1):199-206. [54] Ho TC, Chen SL, Yang YC, Liao CL, Cheng HC, Tsao YP. PEDF

induces p53-mediated apoptosis through PPAR gamma signal-
ing in human umbilical vein endothelial cells. Cardiovasc Res
2007;76(2):213-23.

[43] Maik-Rachline G, Shaltiel S, Seger R. Extracellular phosphoryla-

tion converts pigment epithelium-derived factor from a neuro-
trophic to an antiangiogenic factor. Blood 2005;105(2):670-8.

[44] Becerra SP, Palmer I, Kumar A, et al. Overexpression of fetal

human pigment epithelium-derived factor in Escherichia
coli. A functionally active neurotrophic factor. J Biol Chem
1993;268(31):23148-56.

[55] Andreu-Agullo C, Morante-Redolat JM, Delgado AC, Farinas I.

Vascular niche factor PEDF modulates Notch-dependent stemness
in the adult subependymal zone. Nat Neurosci 2009;12(12):1514-23.

[56] Park K, Lee K, Zhang B, et al. Identiication of a novel inhibitor

of the canonical Wnt pathway. Mol Cell Biol 2011;31(14):3038-51. [45] Alberdi E, Hyde CC, Becerra SP. Pigment epithelium-derived

factor (PEDF) binds to glycosaminoglycans: analysis of the
binding site. Biochemistry 1998;37(30):10643-52.

[57] Tombran-Tink J, Barnstable CJ. Osteoblasts and osteoclasts

express PEDF, VEGF-A isoforms, and VEGF receptors: possible
mediators of angiogenesis and matrix remodeling in the bone.
Biochem Biophys Res Commun 2004;316(2):573-9.

[46] Meyer C, Notari L, Becerra SP. Mapping the type I collagen-bind-

ing site on pigment epithelium-derived factor. Implications for
its antiangiogenic activity. J Biol Chem 2002;277(47):45400-7. [58] Hiratsuka S, Minowa O, Kuno J, Noda T, Shibuya M. Flt-1 lack-

ing the tyrosine kinase domain is suficient for normal develop-
ment and angiogenesis in mice. Proc Natl Acad Sci USA 1998;
95(16):9349-54.

[47] Bilak MM, Becerra SP, Vincent AM, Moss BH, Aymerich MS,

Kuncl RW. Identiication of the neuroprotective molecular region
of pigment epithelium-derived factor and its binding sites on
motor neurons. J Neurosci 2002;22(21):9378-86. [59] Akiyama T, Dass CR, Shinoda Y, Kawano H, Tanaka S,

Choong PF. PEDF regulates osteoclasts via osteoprotegerin and
RANKL. Biochem Biophys Res Commun 2010;391(1):789-94.

[48] Filleur S, Volz K, Nelius T, et al. Two functional epitopes of pig-

ment epithelial-derived factor block angiogenesis and induce dif-
ferentiation in prostate cancer. Cancer Res 2005;65(12):5144-52. [60] Bogan R, Riddle RC, Li Z, et al. A mouse model for human

osteogenesis imperfecta type VI. J Bone Miner Res 2013. [Epub
ahead of print].

[49] Notari L, Baladron V, Aroca-Aguilar JD, et al. Identiication of

a lipase-linked cell membrane receptor for pigment epithelium-
derived factor. J Biol Chem 2006;281(49):38022-37.